科研成就
2018年代表作
1. Miao Zhaoa#, Ying Chena#, Rongcheng Hana⁎, Dan Luo, Libo Du , Qiang Zheng, Lijun Wang, Yuankai Hong, Yang Liu⁎, Yinlin Sha⁎ A facile synthesis of biocompatible, glycol chitosan shelled CdSeS/ZnS QDs for live cell imaging. Colloids and Surfaces B: Biointerfaces. 172 (2018) 752–759.
2. Xinrui Huang, Sha Li, Song Gao, Exploring an Optimal Wavelet-based Filter for Cryo-ET imaging, Scientific reports, 2018, 8(1):2582.
3. Xinrui Huang, Sha Li, Song Gao, Applying a modified wavelet shrinkage filter to improve cryo-EM imaging, Journal of Computational Biology, 2018, 25(9):1-9.
4. Lu X(#), Zhang T(#), Zhu SJ(#), Xun Q, Tong L, Hu X, Li Y, Chan S, Su Y, Sun Y, Chen Y, Ding J, Yun CH(*), Xie H(*), and Ding K(*), Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Mono-drug Efficacy, ACS Med Chem Lett, 2018 Oct 8;9(11):1123-1127. doi: 10.1021/acsmedchemlett.8b00373.
5. Ma R(#), Yun CH(*). Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2912-2917. doi: 10.1016/j.bbrc.2018.08.068.
6. Zhao P(#), Yao MY, Zhu SJ, Chen JY, Yun CH(*). Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem Biophys Res Commun. 2018 Jul 20;502(3):332-337. doi: 10.1016/j.bbrc.2018.05.154.
7. Wang Q(#), Liu F(#), Qi S(#), Qi Z(#), Yan XE(#), Wang B, Wang A, Wang W, Chen C, Liu X, Jiang Z, Hu Z, Wang L, Wang W, Ren T, Zhang S, Yun CH(*), Liu Q(*), Liu J(*). Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384. doi: 10.1016/j.ejmech.2018.03.003.
8. Zhu SJ(#), Zhao P(#), Yang J, Ma R, Yan XE, Yang SY, Yang JW, Yun CH(*), Structural Insights into Drug Development Strategy Targeting EGFR T790M/C797S, Oncotarget, 2018 Jan 10;9(17):13652-13665. doi: 10.18632/oncotarget.24113.
9. Song C(#), Liang L(#), Jin Y, Li Y, Liu Y, Guo L, Wu C, Yun CH(*), and Yin Y(*), RCC2 is a novel p53 target in suppressing metastasis, Oncogene, 2018 Jan 4;37(1):8-17. doi: 10.1038/onc.2017.306. (IF 6.634,Q1)
10. Chang Z# *, Wang X, Wei R, Liu Z, Shan H, Fan G, Hu H. Functional expression and purification of CYP93C20 a membrane-associated cytochrome P450 from Medicago truncatula. Protein Expr Purifi. 2018,150:44-52.