科研成就
2016年代表作
1. Wang A(#), Yan XE(#), Wu H(#), Wang W(#), Hu C, Chen C, Zhao Z, Zhao P, Li X, Wang L, Wang B, Ye Z, Wang J, Wang C, Zhang W, Gray NS, Weisberg EL, Chen L, Liu J(*), Yun CH(*), Liu Q(*), Ibrutinib Targets mutant-EGFR Kinase With a Distinct Binding Conformation, Oncotarget, 2016 Oct 25;7(43):69760-69769. doi: 10.18632/oncotarget.11951
2. Chen JY(#), Liu L, Cao CL, Li MJ, Tan K, Yang X and Yun CH(*), Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase, Sci Rep, 2016 Aug 23;6:31425. doi: 10.1038/srep31425.
3. Fan F(#), He Z(#), Kong LL(#), Chen Q(#), Yuan Q(#), Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH(*), Deng X(*) and Zhou D(*), Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration, Sci Transl Med, 2016 Aug 17;8(352):352ra108. doi: 10.1126/scitranslmed.aaf2304. 封面文章.
4. Liang L(#), Yan XE, Yin Y(*) and Yun CH(*), Structural and biochemical studies of PDGFRA kinase domain, Biochem Biophys Res Commun, 2016 Sep 2;477(4):667-72. doi: 10.1016/j.bbrc.2016.06.117.
5. Liu F(#), Wang B(#), Wang Q(#), Qi Z(#), Chen C(#), Kong LL(#), Chen JY, Liu X, Wang A, Hu C, Wang W, Wang H, Wu F, Ruan Y, Qi S, Liu J, Zou F, Hu Z, Wang W, Wang L, Zhang S, Yun CH(*), Zhai Z(*), Liu J(*), Liu Q(*), Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML), Oncotarget, 2016 Jul 19;7(29):45562-45574. doi: 10.18632/oncotarget.10037.
6. Anastasi S(#), Zhu SJ(#), Ballarò C, Manca S, Lamberti D, Wang LJ, Alemà S, Yun CH(*), Segatto O(*). Lack of Evidence that CYTH2/ARNO Functions as a Direct Intracellular EGFR Activator. Cell. 2016 May 19;165(5):1031-4. doi: 10.1016/j.cell.2016.05.009.
7. Xu Y#, Wu J, Yin CC*, Mao Y*. Unsupervised Cryo-EM Data Clustering through Adaptively Constrained K-Means Algorithm. PLoS One. 2016 Dec 13;11(12):e0167765. doi: 10.1371/journal.pone.0167765.
8. Wei R#, Wang X#, Zhang Y, Mukherjee S, Zhang L, Chen Q, Huang X, Jing S, Liu C, Li S, Wang G, Xu Y, Zhu S, Williams AJ, Sun F*, Yin CC*. Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1. Cell Res. 2016 Sep;26(9):977-94. doi: 10.1038/cr.2016.99. Epub 2016 Aug 30. 封面文章.
9. Shan H#, Wang Z, Zhang F, Xiong Y, Yin CC*, Sun F*. A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules. Protein Cell. 2016 Jan;7(1):46-62. doi: 10.1007/s13238-015-0229-2. Epub 2015 Dec 17.
10. Zhou Q#, Shi X#, Zhang K, Shi C, Huang L, Chang Z*. The Function of Ile-X-Ile Motif in the Oligomerization and Chaperone-Like Activity of Small Heat Shock Protein AgsA at Room Temperature. Protein J, 2016,35(6):401-406.