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科研成就

2019年代表作

1.Shen J(#), Zhang T(#), Zhu SJ(#), Sun M, Tong L, Lai M, Zhang R, Xu W, Wu R, Ding J, Yun CH(*), Xie H(*), Lu X(*), Ding K(*). Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J Med Chem. 2019 Aug 8; 62(15): 7302-7308. doi:10.1021/acs.jmedchem.9b00576.

2. He JB(#), Zhao P(#), Hu ZM, Liu S, Kuang Y, Zhang M, Li B, Yun CH(*), Qiao X(*), Ye M(*). Molecular Characterization and Structural Basis of a Promiscuous C-Glycosyltransferase from Trollius chinensis. Angew Chem Int Ed Engl. 2019 Aug 12;58(33):11513-11520. doi: 10.1002/anie.201905505.

3. Wang J(#), Chen J(#), Wu G(#), Zhang H(#), Chen S(#), Du X, Zhang L, Wang K, Fan J, Gao S, Wu X, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y, Li J(*), Yun CH(*), Cheng H(*). NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes Dev. 2019 May 1;33(9-10):536-549. doi:10.1101/gad.322602.118.

4. Chen Q#, Huang X, Wei R, Zhang L, Yin C. Characterization of influenza virus PR8 strain cultured in embryonated eggs by cryo-electron tomography. Biochem Biophys Res Commun. 2019 Aug 13; 516(1):57-62. doi: 10.1016/j.bbrc.2019.05.161.

5. Chen J#, Xue L, Wei R, Liu S, Yin CC*. The insecticide chlorantraniliprole is a weak activator of mammalian skeletal ryanodine receptor/Ca2+ release channel. Biochem Biophys Res Commun. 2019 Jan 8; 508(2):633-639. doi: 10.1016/j.bbrc.2018.11.180.

6. Wang T#, Zhang L, Shi C, Wei R, Yin C*. Interaction of the Homer1 EVH1 domain and skeletal muscle ryanodine receptor. Biochem Biophys Res Commun. 2019 Jun 30; 514(3):720-725. doi: 10.1016/j.bbrc.2019.04.199.

7. Liu C#, Shi C, Zhu S, Wei R, Yin CC*. Structural and functional characterization of polyethylene terephthalate hydrolase from Ideonella sakaiensis. Biochem Biophys Res Commun. 2019 Jan 1;508(1):289-294. doi: 10.1016/j.bbrc.2018.11.148.

8. Ling Liang#, Yuhua Li#, Xing Tian, Juntuo Zhou*, Lijun Zhong*, Comprehensive lipidomic, metabolomic and proteomic profiling reveals the role of immune system in vitiligoClinical and Experimental Dermatology, 2019, 44(7): e216-e223.

9. Gu M#, Wang M, Guo J, Shi C, Deng J, Huang L, Huang L, Chang Z*. Crystal structure of CYP76AH1 in 4-PI-bound state from Salvia miltiorrhiza. Biochem Biophys Res Commun. 2019511(4):813-819.