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科研成就

2017年代表作

1.Yan XE(#), Zhu SJ(#), Liang L, Zhao P, Choi HG, Yun CH(*), Structural basis of mutant-selectivity and drug-resistance related to CO-1686, Oncotarget, 2017 Jun 21;8(32):53508-53517. doi: 10.18632/oncotarget.18588.

2. Chang Y(#), Lu X(#), Shibu MA(#), Dai YB(#), Luo J, Zhang Y, Li Y, Zhao P, Zhang Z, Xu Y, Tu ZC, Zhang Q, Yun CH(*), Huang CY(*), Ding K(*), Structure-Based Design of N-(3-((1H-pyrazolo[3, 4-b]pyridin-5-yl)ethynyl) Benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors, J Med Chem. 2017 Jul 13;60(13):5927-5932. doi: 10.1021/acs.jmedchem.7b00572  

3. Kong LL(#), Ma R, Yao MY, Yan XE, Zhu SJ, Zhao P, Yun CH(*), Structural pharmacological studies on EGFR T790M/C797S, Biochem Biophys Res Commun, 2017 Jun 24; 488(2):266-272. doi: 10.1016/j.bbrc.2017.04.138.

4. Hu C(#), Wang A(#), Wu H(#), Qi Z(#), Li X(#), Yan XE(#), Chen C, Yu K, Zou F, Wang W, Wang W, Wu J, Liu J, Wang B, Wang L, Ren T, Zhang S, Yun CH(*), Liu J(*), Liu Q(*). Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode. Oncotarget. 2017 Mar 14;8(11):18359-18372. doi: 10.18632/oncotarget.15443.

5. Liang Q(#), Chen Y(#), Yu K(#), Chen C(#), Zhang S(#), Wang A, Wang W, Wu H, Liu X, Wang B, Wang L, Hu Z, Wang W, Ren T, Zhang S, Liu Q, Yun CH(*), Liu J(*). Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem. 2017 May 5;131:107-125. doi: 10.1016/j.ejmech.2017.03.001.

6. Wang A(#), Li X(#), Wu H(#), Zou F(#), Yan XE(#), Chen C, Hu C, Yu K, Wang W, Zhao P, Wu J, Qi Z, Wang W, Wang B, Wang L, Ren T, Zhang S, Yun CH(*), Liu J(*), Liu Q(*). Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. J Med Chem. 2017 Apr 13;60(7):2944-2962. doi: 10.1021/acs.jmedchem.6b01907.

7. Wang G#, Zhang B, Li S, Yang M, Yin C*. Simultaneous microbial reduction of vanadium (V) and chromium (VI) by Shewanella loihica PV-4. Bioresour Technol. 2017 Mar;227:353-358. doi: 10.1016/j.biortech.2016.12.070.

8. Liu C#, Fan G#, Wang Z, Chen HS, Yin CC*. Allosteric conformational changes of human HBV core protein transform its assembly. Sci Rep. 2017 May 3;7(1):1404. doi: 10.1038/s41598-017-01568-9.

9. He B#, Yang D, Qin M, Zhang Y, He B, Dai W, Wang X, Zhang Q, Zhang H*, Yin C*. Increased cellular uptake of peptide-modified PEGylated gold nanoparticles. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):339-345. doi: 10.1016/j.bbrc.2017.10.026.

10. Gui M#, Liu X, Guo D, Zhang Z, Yin CC*, Chen Y*, Xiang Y*. Electron microscopy studies of the coronavirus ribonucleoprotein complex. Protein Cell. 2017 Mar;8(3):219-224. doi: 10.1007/s13238-016-0352-8.
11. Luo D.#,Han R.,Chen Y.,Zheng Q.,Wang L.,Hong Y.,Sha Y*.Design and fabrication of a geometrically ordered hydrophobic interlayer to prepare high-quality QD/SiO2 for cell imaging. 2017, Journal of Biomedical Nanotechnology, 13(10),pp.1344-1353. DOI:10.1166/jbn. 2017.2455

12. Wei M.#,Tian Y.,Wang L.,Hong Y.,Sha Y*.Photocatalytic synthesis of intensely photoluminescent gold nanoclusters and application in cell imaging. 2017, Journal of Nanoparticle Research,19(7),248.DOI: 10.1007/s11051-017-3945-0

13. Zhong J.#*,Sha Y.*,Gan Y.*,Shang G*.A special section on instrumental development and application of atomic force microscopy.(2017) Science of Advanced Materials,9(1),pp.52-54.DOI: 10.1166/sam. 2017.3017